Abelcet^©

• Amphoteracin B in a lipid complex
• Higher doses can be given
• IV formulation only
• Usual Adult dose: up to 5mg/kg OD.
• Give an initial test dose of 1mg (from the first few mls of first dose) over 10 min and observe patient for 30 min before giving rest of infusion slowly over 180minutes.
• Available in 100mg vials, consideration should be made for rounding the dose to the nearest 100mg as appropriate to allow whole vials to be used.
• Less nephrotoxicity and acute side-effects compared to conventional IV amphotericin B.
• No dose adjustment necessary for renal impairment.

Main indications

• Haematology only – restricted agent
• Microbiology advice for other invasive fungal infections

Active against most strains of:

• Aspergillus sp. (not terreus)
• Yeasts e.g. Candida sp. and Cryptococcus neoformans
• Most moulds which cause mucormycosis e.g. Mucor sp.
• Dimorphic fungi e.g. Histoplasma capsulatum
• Some protozoa e.g. Acanthamoebae, Leishmania sp. and Naegaleria sp.

Not active against most strains of:

• Fusarium sp.
• Scedosporium sp.
• Trichosporon sp.
• Aspergillus terreus
• Malassezia furfur
• Dermatophytes e.g. Trichophyton sp.

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.

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