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Isoniazid
Antituberculosis
agent, used in combination with other antituberculosis agents (exception
prophylaxis)
Good
oral bioavailability
Excellent
tissue (including brain) and CSF penetration
Usual
combination dose is 2 tablets of Rifinah – 300 once
a day (if wt>50kg).(This is
a combination agent with rifampicin)
Check
liver function tests prior to starting therapy.Caution in patients with pre-existing liver disease.
Main indications
Mycobacterial
disease as part of combination therapy
Active
against most strains of:
M.tuberculosis
Varying
activity against atypical mycobacteria
Not
active against most strains of:
Non-mycobacterial
bacteria
Page last edited:
09/02/2009
Caution; the antibiotic doses recommended on
this website are intended for adult patients with normal renal and liver
function unless otherwise stated. Dosing advice for patients with renal
impairment is
available here.
