Renal dosing of Voriconazole

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Voriconazole: Dose adjustment for renal impairment

Estimate creatinine clearance (Crcl) using the creatinine clearance calculator

PO

CrCl (ml/min)	Dose
20 – 50	Normal
10 – 20	Normal
<10	Normal

IV

CrCl (ml/min)	Dose
20 – 50	Avoid IV preparation, if possible, in patients with any stage of renal impairment. Accumulation of the vehicle sulfobutylether-B-cyclodextrin occurs-discuss with pharmacy If IV use unavoidable and benefits outweigh possible risks, monitor renal function closely.
10 – 20
<10

Refer to renal pharmacist for advice on dosing in haemodialysis and peritoneal dialysis.

Refer to critical care pharmacist for advice on dosing in CVVH.

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.