Renal dosing of aciclovir

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Aciclovir: Dose adjustment for renal impairment

Cockcroft-Gault CrCl estimates (using the creatinine clearance calculator) should be used for drug dosing rather than the automated MDRD eGFR produced by the clinical chemistry laboratory available on NOTIS.

IV

Crcl (ml/min)	Dose
20 – 50	Normal dose every 12 hours
10 – 20	Normal dose every 24 hours
<10	50% of normal dose every 24hours

Contact microbiology for advice on assays

Oral

Crcl (ml/min)	Dose
20 – 50	Normal
10 – 20	Simplex: 200mg qds Zoster: 800mg tds
<10	Simplex 200mg bd Zoster 800mg bd

Refer to renal pharmacist for advice on dosing in haemodialysis and peritoneal dialysis.

Refer to critical care pharmacist for advice on dosing in CVVH.

For full guidance on the Clinical Management of Chickenpox in adults Click here

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.