Renal dosing of Amoxicillin

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Amoxicillin - Dose adjustment for renal impairment.

Cockcroft-Gault CrCl estimates (using the creatinine clearance calculator) should be used for drug dosing rather than the automated MDRD eGFR produced by the clinical chemistry laboratory available on NOTIS.

Oral

CrCl (ml/min)	Dose
20 – 50	Normal
10 – 20	Normal
<10	250mg-1g every 8 hours.

CrCl (ml/min)	Dose
20 – 50	Normal
10 – 20	Normal
<10	250mg-1g every 8 hours Endocarditis (refer to microbiology) max 6g per day

Refer to renal pharmacist for advice on dosing in haemodialysis and peritoneal dialysis.

Refer to critical care pharmacist for advice on dosing in CVVH.

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.