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Oseltamivir (treatment dose) - Dose adjustment for renal impairment.

Cockcroft-Gault CrCl estimates (using the creatinine clearance calculator) should be used for drug dosing rather than the automated MDRD eGFR produced by the clinical chemistry laboratory available on NOTIS.

Oral Treatment doses (Recommended duration 5 days)

CrCl (ml/min)	Dose
>30	75mg bd
10 – 30	75mg od (30mg bd when started by primary care)
<10	30mg as a single dose (remains in body for 10 days)
Haemodialysis (high flux)/ Haemodiafiltration	75mg stat and then 75mg after each HD session
CVVH	75mg od
CAPD	30mg repeated after 1 week if continuation beyond 5 days is advised by microbiology or infectious diseases (remains in body for 7 days)

Oral Prophylactic dosing (Recommended duration 10 days)

CrCl (ml/min)	Dose
>30	75mg od (normal dose)
10 – 30	75mg every 48 hours (or 30mg once daily if started in primary care)
<10	30mg every 10 days if continuation beyond 10 days is advised by microbiology or infectious diseases.
Haemodialysis (high flux)/ haemodiafiltration	75mg stat and then 75mg after each HD session
CVVH	75mg every 48 hours or 30mg od
CAPD	30mg repeated after 1 week (remains in body for 7 days)

Refer to renal pharmacist for advice on dosing in haemodialysis and peritoneal dialysis.

Refer to critical care pharmacist for advice on dosing in CVVH.

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.