Guidelines For The Empirical Treatment Of Sepsis In Adults

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Antibiotic Guideline for the Treatment of Endocarditis:

Endocarditis when allergic to penicillins:

++All therapy and investigation should be discussed with Microbiology / Infectious Diseases.++

Enterococci.

Gentamicin sensitive or low level resistant (MIC < 100 mg/l)

Vancomycin IV 1 g BD (adjust dose if >65 yrs or renal impairment; monitor levels) plus Gentamicin IV 1.5mg/kg BD click here for duration.

Gentamicin highly resistant (MIC > 2000 mg/l)

Vancomycin IV 1 g BD (adjust dose if >65 yrs or renal impairment; monitor levels) Streptomycin can be given if strain is sensitive following discussion with microbiology) for duration discuss with microbiology.

Page last edited: 31/10/2008

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.