Antibiotic Guideline for the Empirical Treatment of Sepsis: 

Severe Sepsis of Unknown Origin

Does the patient have ANY of the following:

• Previous isolation of ESBL positive E.coli or multi resistant gram negative (MRGNB)

                    OR

• Recurrent urinary or biliary tract infections (greater than 2 in last year)
• Sepsis despite current or recent (within the last week) treatment with broad spectrum antibiotics e.g. co-amoxiclav, cefuroxime or quinolones e.g. levofloxacin, ciprofloxacin

                                    Yes            No

Page last edited: 08/05/2009

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.

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