Sodium
fusidate (fusidic acid)
-
Bactericidal
-
Usual
adult dose: 250mg – 500mg bd or tds
-
Excreted
in bile therefore no need to reduce dose if renal
impairment.
-
Monitor
LFTs during therapy
-
Mostly
used with another anti-staphylococcal agent to prevent resistance.
-
Penetrates
well into bone and tissue – including necrotic tissue
-
Resistance
develops quickly if used as monotherapy for systemic infections.
- Topical treatment also available for
conjunctivitis and minor skin sepsis.*
Main
indications:
- Adjunctive therapy for complicated
staphylococcal infections
Active
against most strains of:
Not
active against most strains of:
*Many
“impetigo” strains of S aureus are now fusidic acid resistant.
Page last edited:
09/02/2009
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