Renal dosing of Amphotericin and liposomal amphotericin

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Lipid associated amphotericin (Abelcet and Ambisome)

Dose adjustment for renal impairment

Cockcroft-Gault CrCl estimates (using the creatinine clearance calculator) should be used for drug dosing rather than the automated MDRD eGFR produced by the clinical chemistry laboratory available on NOTIS.

Crcl (ml/min)	Dose
20 – 50	Normal - see note below
10 – 20	Normal - see note below
<10	Normal - see note below

Amphotericin is highly NEPHROTOXIC - Daily monitoring of renal function is essential

For further advice on dosing and administration see web page for ambisome and abelcet, local guidelines and Trust IV guide

Refer to renal pharmacist for advice.

Refer to critical care pharmacist for advice on dosing in CVVH.

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.