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IV to PO Switch Guideline - Recommended Empiric Alternatives

N.B. Check for allergies / interactions / microbiology results

 

IV

Oral
Amoxicillin 500mg-1g tds Amoxicillin 500mg-1g tds
Cefuroxime 750mg-1.5g tds plus Metronidazole 500mg tds Co-amoxiclav 375mg tds plus Amoxicillin 250mg tds

OR

Cefalexin 500mgs tds and Metronidazole 400mg tds
Cefuroxime 750mg-1.5g tds Co-amoxiclav 375mg plus Amoxicillin 250mg tds

OR

Cefalexin 500mgs tds

Co-amoxiclav 1.2g tds Co-amoxiclav 375mg plus Amoxicillin 250mg tds
Clindamycin 900mg qds Clindamycin 300-450mg qds can use a maximum of 600mg qds if severe infection (for more info see here).
 

Flucloxacillin 2g qds

 Flucloxacillin 1g qds

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.

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