Ceftazidime:

• A 3^rd generation cephalosporin antibiotic

• Bactericidal

• Resistant to most ß-lactamases

• Good anti-pseudomonal activity

• Usual adult dose: 1g tds

• Dosage adjustment needed if renal impairment

• Can be given IV or IM; no oral preparation available

• Penetrates well into bile, bone, heart and synovial, pleural and peritoneal fluids. Only penetrates into CSF in presence of inflammation.

• Not to be used in patients with a serious penicillin allergy (e.g. anaphylaxis).

Main indications:

• Likely pseudomonal infections

• Febrile neutropenia (in oncology patients)

Active against most strains of:

• Haemophilus influenzae

• Escherichia coli

• Klebsiella

• Other coliforms

• Pseudomonas aeruginosa
• Streptococci

Not active against most strains of:

• Staphylococcus aureus

• Enterococcus

• Listeria monocytogenes
• Anaerobes

Page last edited: 09/02/2009

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.

Read our copyright and disclaimer statement