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IV to PO Switch Guideline - Recommended Empiric Alternatives

N.B. Check for allergies / interactions / microbiology results

 

IV

Oral
Amoxicillin 500mg-1g tds Amoxicillin 500mg-1g tds
Cefuroxime 750mg-1.5g tds plus Metronidazole 500mg tds Co-amoxiclav 375mg tds plus Amoxicillin 250mg tds
Cefuroxime 750mg-1.5g tds Co-amoxiclav 375mg plus Amoxicillin 250mg tds
Clarithromycin 500mg bd Clarithromycin 500mg bd
Flucloxacillin 2g qds Flucloxacillin 1g qds
Clindamycin 600mg qds Clindamycin 300-450mg qds can use a maximum of 600mg qds if severe infection (for more info see here).
Ciprofloxacin 400mg bd Ciprofloxacin 500mg bd (750mg bd recommended for Pseudomonas sp.) As ciprofloxacin can increase selection for C.difficile infection and MRSA colonisation/infection, all patients with previous MRSA/C.difficile  require microbiology approval to use ciprofloxacin.
Co-amoxiclav 1.2g tds Co-amoxiclav 375mg plus Amoxicillin 250mg tds
Piperacillin/tazobactam (Tazocin), meropenem, vancomycin Seek advice from microbiology


 

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.

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